Ion channels as antivirus targets

X Liang, Z Li - Virologica Sinica, 2010 - Springer
… a group of viral channel proteins that … channel-forming proteins may be “lethal”, which can
be a suitable and potential therapeutic strategy. In this review we discuss seven ion channels

Coronaviral ion channels as target for Chinese herbal medicine

S Schwarz, D Sauter, W Lu, K Wang, B Sun… - Onco …, 2012 - dl.begellhouse.com
… that viral ion channels, in general, may be good targets for the development of antiviral agents,
… of known antiviral phytochemicals on the ionchannel-forming 3a protein of coronavirus. …

Viral dependence on cellular ion channels–an emerging anti-viral target?

S Hover, B Foster, JN Barr… - Journal of General …, 2017 - microbiologyresearch.org
… targeting ion channels pharmacologically can impede virus life cycles. Here, we discuss
current examples of virus–ion channel interactions and the potential of targeting ion channel

[HTML][HTML] Viral proteins function as ion channels

K Wang, S Xie, B Sun - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
… Viral ion channels are short membrane proteins with 50–120 … advances in viral encoded ion
channel proteins (or viroporins), … viral ion channel protein serving as a potential drug target. …

Viroporins: structure, function and potential as antiviral targets

C Scott, S Griffin - Journal of General Virology, 2015 - microbiologyresearch.org
… as an antiviral drug target. This review attempts to summarize our current understanding of
the channel-… Ultimately, given the successes of drugs targeting ion channels in other areas of …

[HTML][HTML] Modulation of adaptive immunity and viral infections by ion channels

K Bohmwald, NMS Gálvez, CA Andrade… - Frontiers in …, 2021 - frontiersin.org
… cells, Ca 2+ channels function can be altered, … ion channels and ion transporters that are
essential for the function of immune cells. Specifically, cation channels and Ca 2+ channels in …

Put a cork in it: Plugging the M2 viral ion channel to sink influenza

PH Jalily, MC Duncan, D Fedida, J Wang, I Tietjen - Antiviral research, 2020 - Elsevier
… -selective ion channel that is required for virus replication and is an established antiviral target.
… mutations, and ongoing efforts to develop new antivirals that target resistant forms of M2. …

Genistein as antiviral drug against HIV ion channel

D Sauter, S Schwarz, K Wang, R Zhang, B Sun… - Planta …, 2014 - thieme-connect.com
… tool to screen drugs for their potency in inhibition of ion channel activity. The viral protein U-…
that viral ion channels, in general, may be a good target for development of antiviral agents, …

Molecular design, synthesis and biological evaluation of cage compound-based inhibitors of hepatitis C virus p7 ion channels

VA Shiryaev, EV Radchenko, VA Palyulin… - European Journal of …, 2018 - Elsevier
… with small-molecule inhibitors may provide an attractive option in antiviral development.
The … (and many other ion channels) makes them suitable targets for the cage compound …

[PDF][PDF] Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

TL Foster, M Verow, AL Wozniak, MJ Bentham… - …, 2011 - Wiley Online Library
channel function in vitro and virion production in culture, rendering it an attractive antiviral
target.… points26,27 supports a specific antiviral effect, and selection of specific nonsynonymous …